Prime™ Isotonix® Joint Support Formula

Benefits:

• Helps promote normal cartilage synthesis and regeneration
• Aids in maintaining joint comfort
• Supports joint smoothness and flexibility
• Supports overall joint health

This product is not intended to diagnose, treat, or prevent any disease.

Product Classification:

• Gluten-Free: This product contains no detectable gluten.*
• Non-GMO: This product contains no detectable genetically modified organisms (GMOs).
• Isotonic Nutritional Supplement Drink: An easy-to-drink nutritional supplement/health food that achieves better nutrient absorption through an isotonic state.
• Quality Standards: Operates under Good Manufacturing Practices (GMP) with standardized ingredients.
• Tested for: Heavy metals, microbial contaminants, allergens, potency, purity, and characteristics.

*The U.S. Food and Drug Administration (FDA) defines products containing less than 20 PPM of gluten as gluten-free.

Details:

As the body ages, many people experience joint discomfort. One way to improve this is by using joint nutritional supplements to promote overall bone and joint health. Prime Isotonix Joint Support Formula directly provides hyaluronic acid, which is crucial for maintaining tissue moisture and lubrication. This product also contains glucosamine, a naturally occurring component in the body that is essential for cartilage formation. Glucosamine, an amino sugar (a combination of the amino acid glutamine and glucose), is concentrated in joint cartilage and supports healthy joint function. Prime Isotonix Joint Support Formula also includes the powerful antioxidant Pycnogenol®†.

Prime Isotonix Joint Support Formula is a unique product that delivers glucosamine, Pycnogenol, and hyaluronic acid in an isotonic form.

"Isotonic" means "same pressure," which refers to having the same chemical characteristics as the body's blood, plasma, and tears. All fluids in the body have a specific concentration, known as osmotic pressure. The body's usual osmotic pressure is isotonic, allowing tissues to maintain a consistent level. For a substance to be absorbed and used in metabolism, it must be in an isotonic solution state.

Isotonix nutritional supplements are delivered in an isotonic solution, meaning the body can efficiently absorb the nutrients with minimal effort. This isotonic suspension allows nutrients to enter the small intestine directly and be rapidly absorbed into the bloodstream. The nutrient loss through Isotonix products is minimal, promoting efficient nutrient absorption for optimal results.

†Pycnogenol® is a registered trademark of Horphag Research Ltd. This product is protected by one or more U.S. patents and other international patents.

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Isotonix® Delivery System

The Isotonix product line is one of the most effective ways to deliver nutritional supplements. The formulas use advanced and scientifically proven ingredients to provide efficient delivery and superior results.

Isotonix products are isotonic because they contain almost the same concentration of solutes, such as salts, sugars, and minerals, as the body's fluids. At this concentration, nutrients and molecules can effectively pass through cell walls for cellular metabolism. The balanced combination of fructose, glucose, citric acid, potassium bicarbonate, and other key ingredients in Isotonix formulas ensures that the solution reaches an isotonic state when properly mixed for consumption.

Isotonix products deliver nutrients in the right proportions and concentrations for optimal absorption. Isotonix is one of the most scientifically proven effective nutrient delivery systems on the market.

Ingredients

Glucosamine

Glucosamine is a molecule naturally synthesized by the body using glucose and the amino acid glutamine. It is a crucial component of cartilage matrix and joint fluid glycosaminoglycans. As the body ages, the ability to produce glucosamine decreases, leading to weaker cartilage and reduced flexibility. Although the exact mechanism is unknown, studies show that supplementing with glucosamine can support the production of normal, healthy cartilage cells, promoting overall joint health.

Pine Bark Extract (Pycnogenol®)

Pycnogenol is a water-soluble flavonoid complex with powerful benefits. Similar to proanthocyanidins found in grape seeds, Pycnogenol is extracted from the bark of French maritime pine trees. Studies show that Pycnogenol helps maintain the body's natural defenses and supports good health. Additionally, research indicates that Pycnogenol supports the cross-linking of collagen fibers and other connective tissues.

Hyaluronic Acid

Hyaluronic acid is essential for maintaining tissue moisture and lubrication. Although the body can naturally produce hyaluronic acid, its levels decrease with age, causing joint discomfort. Hyaluronic acid is a crucial component of cartilage and is vital for joint health. Studies show that hyaluronic acid helps maintain strong cartilage and promotes the production of joint fluid.

FAQs

Who should take Prime Isotonix Joint Support Formula?

This product is suitable for adults only. Any adult looking to support and maintain joint health can use this product.

What products should be used with Prime Isotonix Joint Support Formula to support joint health?

Heart Health™ Omega-3 Fish Oil and Prime Isotonix Joint Support Formula make a great combination, as the omega-3 fatty acids in fish oil are proven to support healthy lubricated joint function.

How do I take Prime Isotonix Joint Support Formula?

Pour two white screw capfuls of powder into a cup, add 120 ml of water, stir, and drink. This product is a health food and should be taken once daily or as directed by a healthcare professional. For best results, take on an empty stomach. Use the specified amount of powder and water to achieve an isotonic state.

How much Pycnogenol® is in Prime Isotonix Joint Support Formula?

Each daily serving contains 25 mg of Pycnogenol.

Is this product labeled as "non-GMO"?

This product contains no detectable genetically modified organisms. The raw materials in this product may contain genetically modified materials/ingredients, but the final product does not contain any transgenic gene fragments or transgenic proteins.

Is it safe to take Prime Isotonix Joint Support Formula?

Prime Isotonix Joint Support Formula is safe and free of harmful substances. It is manufactured in the USA in facilities inspected by the U.S. Food and Drug Administration (FDA) and complies with Good Manufacturing Practices. Customers can have complete confidence in the quality and safety of this product.

Science

• Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
• Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
• Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
• Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
• Chang, X., et al. Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis. Arthritis Research and Therapy. 7(2): R268-R273, 2005.
• Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
• Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
• Elliott, A., et al. Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project. Arthritis and Rheumatism. 52(1): 105-111, 2005.
• Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
• Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
• Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
• Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
• Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
• James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
• Julovi, S., et al. Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage. Arthritis and Rheumatism. 50(2): 516-525, 2004.
• Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
• Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
• McDonald, J. and Levick, J. Hyaluronan reduces fluid escape rate from rabbit knee joints disparately from its effect on fluidity. Experimental Physiology. 79(1): 103-106, 1994.
• Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
• Ohno, S., et al. Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. Journal of Biological Chemistry. 281(26): 17952-17960, 2006.
• Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
• Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
• Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
• Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
• Santangelo, K., et al. Effects of hyaluronan treatment on lipopolysaccharide-challenged fibroblast-like synovial cells. Arthritis Research and Therapy. 9(1): R1, 2007.
• Sasaki, A., et al. Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. The Tohoku Journal of Experimental Medicine. 204(2): 99-107, 2004.
• Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.